Towards new fungal enzyme inhibitors via five and six membered nitrones
- Mattia Ghirardello
- Fernando Gomollón-Bel
- David Sádaba
- Tomás Tejero
- Pedro Merino
Editorial: /
Año de publicación: 2013
Congreso: 15th JCF Frühjahrssymposium (Congreso de Jóvenes Investigadores de la Sociedad Alemana de Química) (15º. 2013. Alemania)
Tipo: Póster de Congreso
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Even though they are not the most understood molecules in biology, it is well known that glycans are a primary class of biomolecules, as important as DNA, RNA, proteins or lipids. For instance, carbohydrates decorate the surface of most cells directing the interactions between them. Therefore, studying the enzymes that synthesize and modify membrane-attached glycans may lead to the understanding of very important biological pathways. Also, by preparing and studying modified sugars to inhibit this enzymes we can achieve potencial antibiotics, fungicides or antitumoral agents. In our laboratory, thanks to the vast experience we have in the chemistry of nitrones, we are developing several methods for the preparation of five and six membered nitrones that can be functionalized and then reduced to give pirrolidines and piperidines, classic inhibitors of glycosidases and transglycosidades. The products obtained are currently being tested in molecular docking, molecular dynamics and inhibition assays.