Derivation of Optimal Experimental Design Methods for Applications in Cytogenetic Biodosimetry

  1. Higueras, Manuel 1
  2. López-Fidalgo, Jesús 2
  1. 1 Universidad de La Rioja
    info

    Universidad de La Rioja

    Logroño, España

    ROR https://ror.org/0553yr311

  2. 2 Universidad de Navarra
    info

    Universidad de Navarra

    Pamplona, España

    ROR https://ror.org/02rxc7m23

Libro:
Statistical Methods at the Forefront of Biomedical Advances
  1. Yolanda Larriba (ed. lit.)

Editorial: Springer

ISBN: 9783031327285,  9783031327292

Año de publicación: 2023

Páginas: 143-155

Tipo: Capítulo de Libro

DOI: 10.1007/978-3-031-32729-2_7 GOOGLE SCHOLAR lock_openAcceso abierto editor

Resumen

The definition of cytogenetic dose–response curves implies the irra-diation of in vitro blood samples to different ionizing radiation dose levels.Here, optimal experimental design techniques are applied to these curves. Thisoptimization is mainly focused on the selection of dose levels. As cytogenetic doseestimation leads to a calibration problem, an optimal design criterion for calibrationpurposes is explained here.

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