Highly Emissive Hybrid Mesoporous Organometallo-Silica Nanoparticles for Bioimaging
- Jesús R. Berenguer 2
- Cintia Ezquerro 2
- Elena Lalinde 2
- Elena Serrano 3
- Javier García-Martínez 3
- Elvira Alfaro-Arnedo 1
- Icíar P. López 1
- José G. Pichel 1
- Ignacio M. Larráyoz 1
- 1 Centro de Investigación Biomédica de La Rioja (CIBIR)
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2
Universidad de La Rioja
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3
Universitat d'Alacant
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Editorial: Real Sociedad Española de Química
ISBN: 978-84-09-42159-6
Any de publicació: 2022
Pàgines: 1212
Congrés: XXXVIII Reunión Bienal de la Real Sociedad Española de Química (RSEQ Granada 2022) 27-30 de junio de 2022
Tipus: Pòster de congrés
beta Ver similares en nube de resultadosResum
Production of Mesoporous Silica Nanoparticles (MSNs) with uniform textural characteristics and imaging properties on a large scale is still a challenge. Thus, the design of simple and scalable methods to obtain reproducible functionalized MSNs has become even more relevant.In this communication, we describe an in-situ strategy for the synthesis and superficial functionalization of highly luminescent Mesoporous Organometallo-Silica Nanoparticles. Using the [Ir(dfppy)2(dasipy)]PF6 chromophore and TEOS as sol-gel precursors, and different capping agents, such as diethoxydimethylsilane (DMDES) or 3-aminopropyltriethoxysilane (APTES), three different emissive MSNs were prepared (NPOH_IS, NPMe_IS and NPNH2_IS), each containing hydroxyl, methyl or amine groups on their surfaces, respectively. All three have been tested on human tumor A549 (lung carcinoma) and HeLa (cervix carcinoma) cell lines, showing intense and stable yellow phosphorescence, biocompatibility and efficient internalization. Moreover, these MSNs also present excellent textural properties with high superficial areas (up to 1000 m2·g-1), paving the road for their future use not only as phosphorescent biomarkers, but also in controlled intramolecular delivery.[1]
Referències bibliogràfiques
- [1] C. Ezquerro, I. López, E. Serrano, E. Alfaro-Arnedo, E. Lalinde, I. Larráyoz, J. G. Pichel, J. García-Martínez, Mater. Ad. 2022, DOI: 10.1039/D1MA01243F.