Design And Multi-Gram Synthesis of UV Filters Based On Natural Products
- Beatriz Peñín 1
- Jacobo Soilán 1
- Raúl Losantos 1
- Almudena Terrel 1
- Aída Muro 1
- Ignacio Funes-Ardoiz 1
- Diego Sampedro 1
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1
Universidad de La Rioja
info
Editorial: Universidad Alcalá de Henares
Año de publicación: 2022
Páginas: 137-138
Congreso: VII jornadas ibéricas de fotoquímica. Alcalá de Henares, Madrid, Spaini. September, 5-8 2022.
Tipo: Aportación congreso
Resumen
The UV light is a potentially harmful stimulus for living organisms. This is caused by highlyenergetic UV-A wavelengths (320-400nm) that are not filtered by the atmosphere. Absorptionof such photons may induce photochemical reactions that may lead to cancer or death.1Nonetheless, to minimize this problem, it is necessary to design compounds with adequatephotoprotecting mechanisms suitable for human use.2 These UV filters should fulfil a longlist of requirements, including photo-, chemical and thermal stability, an efficient energymechanism, and, recently, a certain degree of biodegradability.Specifically, in this work, we have synthesized a variety of UV filters, which absorb theUV-Vis irradiation in the relevant range. We based our design on the structure of naturalphotoprotective molecules. In addition, we explored their ability to photoprotect differentsurfaces, including human skin. With this purpose, we have studied the photoprotectiveproperties of the different filters, analyzing the photoprotection mechanisms bycomputational methods, and measuring the shape and position of the UV-Vis absorbanceband to select the best structure for the absorption of the UV-A irradiation which is the mostharmful for living organisms.Finally, we have scaled the synthesis of selected compounds to allow for commercialapplications