Prediabetes Is Associated with Increased Prevalence of Sleep-Disordered Breathing

  1. Sánchez, Enric
  2. Sapiña-Beltrán, Esther
  3. Gavaldà, Ricard
  4. Barbé, Ferran
  5. Torres, Gerard
  6. Sauret, Ariadna
  7. Dalmases, Mireia
  8. López-Cano, Carolina
  9. Gutiérrez-Carrasquilla, Liliana
  10. Bermúdez-López, Marcelino
  11. Fernández, Elvira
  12. Purroy, Francisco
  13. Castro-Boqué, Eva
  14. Farràs-Sallés, Cristina
  15. Pamplona, Reinald
  16. Mauricio, Dídac
  17. Hernández, Cristina
  18. Simó, Rafael
  19. Lecube, Albert
  20. on behalf of the ILERVAS Project Collaborators
Aldizkaria:
Journal of Clinical Medicine

ISSN: 2077-0383

Argitalpen urtea: 2022

Alea: 11

Zenbakia: 5

Orrialdeak: 1413

Mota: Artikulua

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DOI: 10.3390/JCM11051413 GOOGLE SCHOLAR lock_openSarbide irekia editor

Beste argitalpen batzuk: Journal of Clinical Medicine

Gordailu instituzionala: lock_openSarbide irekia Editor

Garapen Iraunkorreko Helburuak

Laburpena

Type 2 diabetes leads to severe nocturnal hypoxemia, with an increase in apnea eventsand daytime sleepiness. Hence, we assessed sleep breathing parameters in the prediabetes stage.A cross-sectional study conducted on 966 middle-aged subjects without known pulmonary disease(311 patients with prediabetes and 655 controls with normal glucose metabolism) was conducted.Prediabetes was defined by glycated hemoglobin (HbA1c), and a nonattended overnight home sleep study was performed. Participants with prediabetes (n = 311) displayed a higher apnea–hypopneaindex (AHI: 12.7 (6.1;24.3) vs. 9.5 (4.2;19.6) events/h, p < 0.001) and hypopnea index (HI: 8.4 (4.0;14.9)vs. 6.0 (2.7;12.6) events/h, p < 0.001) than controls, without differences in the apnea index. Altogether,the prevalence of obstructive sleep apnea was higher in subjects with prediabetes than in controls(78.1 vs. 69.9%, p = 0.007). Additionally, subjects with prediabetes presented impaired measurementsof the median and minimum nocturnal oxygen saturation, the percentage of time spent with oxygensaturations below 90%, and the 4% oxygen desaturation index in comparison with individualswithout prediabetes (p < 0.001 for all). After adjusting for age, sex, and the presence of obesity,HbA1c correlated with the HI in the entire population (r = 0.141, p < 0.001), and the presence ofprediabetes was independently associated with the AHI (B = 2.20 (0.10 to 4.31), p = 0.040) as well asthe HI ( B = 1.87 (0.61 to 3.14), p = 0.004) in the multiple linear regression model. We conclude thatprediabetes is an independent risk factor for an increased AHI after adjusting for age, sex, and obesity.The enhanced AHI is mainly associated with increments in the hypopnea events.

€ Ikusi finantzaketa

Finantzaketari buruzko informazioa

Finantzatzaile

  • Lleida Provincial Council, Autonomous Government of Catalonia
    • 2017SGR696 and SLT0021600250
  • Instituto de Salud Carlos III
    • PI12/00803, PI15/00260 and PI18/00964

Erreferentzia bibliografikoak

  • 10.1210/er.2017-00173
  • 10.1371/journal.pone.0119073
  • 10.1111/dme.13161
  • 10.1371/journal.pone.0157579
  • 10.1371/journal.pone.0004692
  • 10.3390/jcm9041022
  • 10.1016/j.chest.2017.05.009
  • 10.2337/dc18-0675
  • 10.1155/2012/902324
  • 10.1016/j.nefro.2016.02.008
  • 10.1016/j.rec.2020.09.015
  • (2017), Diabetes Care, 40, pp. S11
  • 10.1373/clinchem.2014.224311
  • 10.5664/jcsm.26861
  • 10.5664/jcsm.6506
  • 10.1093/sleep/14.6.540
  • 10.1016/j.diabres.2008.04.025
  • 10.1186/1475-2840-10-84
  • 10.1038/oby.2007.169
  • 10.2337/dc09-1901
  • Vgontzas, (2001), J. Clin. Endocrinol. Metab., 86, pp. 517
  • 10.1038/sj.ijo.0801272
  • 10.2147/NSS.S124657
  • 10.1007/s00405-016-4103-5
  • 10.1183/09031936.00166808
  • 10.2337/dc19-2367
  • 10.1113/JP270308
  • 10.1016/S0140-6736(08)61622-0
  • 10.1136/bmjopen-2016-013983
  • 10.1186/s12933-019-0962-6
  • López-Cano, (2019), PLoS ONE., 14, 10.1371/journal.pone.0211742
  • 10.1371/journal.pone.0061382
  • 10.1111/jsr.12552
  • 10.1513/AnnalsATS.201510-697OC
  • 10.1038/ijo.2016.52
  • 10.1038/s41387-019-0098-5
  • 10.1016/j.psyneuen.2019.104444
  • 10.1016/j.diabres.2004.06.003