On the boundaries of computational organic chemistryfrom pericyclic to enantioselective cyclizations and transition metal catalysed reactions
- Villar Cruces, Pedro
- Ángel Rodríguez de Lera Co-director
- Rosana Álvarez Rodríguez Co-director
Defence university: Universidade de Vigo
Fecha de defensa: 25 February 2021
- José Joaquín Quirante Sánchez Chair
- Ignacio Funes Ardoiz Secretary
- Theresa Sperger Committee member
Type: Thesis
Abstract
The Nahuoic acid has been characterized as a demethylase enzymes inhibitor. The objectives of this project are: The study and characterization, using computational chemistry, of the intramolecular Diels-Alder reaction which is the key step of the nahuoic acid total syntheses and also the study of the interaction between this molecule and the epigenetic enzyme SETD8 employing molecular modelling.