Cycloadditions of cyclohexynes and cyclopentyne
- Medina, J.M. 1
- McMahon, T.C. 1
- Jiménez-Osés, G. 1
- Houk, K.N. 1
- Garg, N.K. 1
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1
University of California Los Angeles
info
ISSN: 0002-7863
Year of publication: 2014
Volume: 136
Issue: 42
Pages: 14706-14709
Type: Article
More publications in: Journal of the American Chemical Society
Abstract
We report the strategic use of cyclohexyne and the more elusive intermediate, cyclopentyne, as a tool for the synthesis of new heterocyclic compounds. Experimental and computational studies of a 3-substituted cyclohexyne are also described. The observed regioselectivities are explained by the distortion/interaction model. © 2014 American Chemical Society.