Chromosomal integration of the novel plasmid pUR3912 from methicillin-susceptible Staphylococcus aureus ST398 of human origin

  1. Gómez-Sanz, E. 1
  2. Zarazaga, M. 1
  3. Kadlec, K. 2
  4. Schwarz, S. 2
  5. Torres, C. 1
  1. 1 Universidad de La Rioja
    info

    Universidad de La Rioja

    Logroño, España

    ROR https://ror.org/0553yr311

  2. 2 Institute of Farm Animal Genetics, Friedrich-Loeffler-Institut (FLI), Neustadt-Mariensee, Germany
Revue:
Clinical Microbiology and Infection

ISSN: 1198-743X

Année de publication: 2013

Volumen: 19

Número: 11

Pages: E519-E522

Type: Article

DOI: 10.1111/1469-0691.12279 SCOPUS: 2-s2.0-84885477448 WoS: WOS:000325564400029 GOOGLE SCHOLAR lock_openAccès ouvert editor

D'autres publications dans: Clinical Microbiology and Infection

Dépôt institutionnel: lock_openAccès ouvert Editor

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Resistencia bacteriana a antimicrobianos en ambiente y fauna salvaje. Mecanismos de resistencia y líneas genéticas emergentes e implicaciones en salud humana

2013/00001/001

Résumé

The novel erm(T)-cadDX-carrying plasmid pUR3912 has recently been described in the methicillin-susceptible Staphylococcus aureus ST398-t571 strain C3912 from a healthy human in Spain. Structural analysis revealed that pUR3912 belongs to the pC194 replicon family, replicates via a rolling circle mechanism and harbours putative double-strand (dso) and single-strand (sso) origins of replication. Besides its plasmid location, a copy of pUR3912 was also found in the chromosomal DNA of strain C3912. Two IS431 copies, which flank the plasmid, most probably mediated its chromosomal integration. Its ability to not only exist extrachromosomally, but also to integrate into the chromosomal DNA ensures persistence and dissemination of pUR3912. © 2013 European Society of Clinical Microbiology and Infectious Diseases.