Economic Features of Antibiotic Resistance: The Case of Methicillin-Resistant Staphylococcus aureus

  1. Antonanzas, F. 1
  2. Lozano, C. 1
  3. Torres, C. 1
  1. 1 Universidad de La Rioja

    Universidad de La Rioja

    Logroño, España



ISSN: 1170-7690

Year of publication: 2015

Volume: 33

Issue: 4

Pages: 285-325

Type: Article

DOI: 10.1007/S40273-014-0242-Y SCOPUS: 2-s2.0-84939986716 WoS: WOS:000352276300001 GOOGLE SCHOLAR

More publications in: PharmacoEconomics


Cited by

  • Scopus Cited by: 41 (07-05-2023)
  • Web of Science Cited by: 42 (20-05-2023)
  • Dimensions Cited by: 45 (30-03-2023)

JCR (Journal Impact Factor)

  • Year 2015
  • Journal Impact Factor: 2.566
  • Journal Impact Factor without self cites: 2.251
  • Article influence score: 0.893
  • Best Quartile: Q1
  • Area: ECONOMICS Quartile: Q1 Rank in area: 27/345 (Ranking edition: SSCI)
  • Area: HEALTH POLICY & SERVICES Quartile: Q1 Rank in area: 11/75 (Ranking edition: SSCI)
  • Area: HEALTH CARE SCIENCES & SERVICES Quartile: Q2 Rank in area: 23/88 (Ranking edition: SCIE)
  • Area: PHARMACOLOGY & PHARMACY Quartile: Q2 Rank in area: 104/255 (Ranking edition: SCIE)

SCImago Journal Rank

  • Year 2015
  • SJR Journal Impact: 1.143
  • Best Quartile: Q1
  • Area: Health Policy Quartile: Q1 Rank in area: 33/253
  • Area: Public Health, Environmental and Occupational Health Quartile: Q1 Rank in area: 92/548
  • Area: Pharmacology Quartile: Q1 Rank in area: 84/345


  • Social Sciences: A+

Scopus CiteScore

  • Year 2015
  • CiteScore of the Journal : 5.3
  • Area: Health Policy Percentile: 93
  • Area: Public Health, Environmental and Occupational Health Percentile: 90
  • Area: Medicine (all) Percentile: 76
  • Area: Pharmacology Percentile: 73


(Data updated as of 30-03-2023)
  • Total citations: 45
  • Recent citations: 17
  • Relative Citation Ratio (RCR): 2.07
  • Field Citation Ratio (FCR): 9.02


This paper analyses and updates the economic information regarding methicillin-resistant Staphylococcus aureus (MRSA), including information that has been previously reviewed by other authors, and new information, for the purpose of facilitating health management and clinical decisions. The analysed articles reveal great disparity in the economic burden on MRSA patients; this is mainly due to the diversity of the designs of the studies, as well as the variability of the patients and the differences in health care systems. Regarding prophylactic strategies, the studies do not provide conclusive results that could unambiguously orientate health management. The studies addressing treatments noted that linezolid seems to be a cost-effective treatment for MRSA, mostly because it is associated with a shorter length of stay (LOS) in hospital. However, important variables such as antimicrobial susceptibility, infection type and resistance emergence should be included in these analyses before a conclusion is reached regarding which treatment is the best (most efficient). The reviewed studies found that rapid MRSA detection, using molecular techniques, is an efficient technique to control MRSA. As a general conclusion, the management of MRSA infections implicates important economic costs for hospitals, as they result in higher direct costs and longer LOS than those related to methicillin-susceptible S. aureus (MSSA) patients or MRSA-free patients; there is wide variability in those increased costs, depending on different variables. Moreover, the research reveals a lack of studies on other related topics, such as the economic implications of changes in MRSA epidemiology (community patients and lineages associated with farm animals).