Methicillin-resistant Staphylococcus aureus (MRSA) ST398 in a farmer with skin lesions and in pigs his farm: clonal relationship and detection of lnu(A) gene.

  1. Lozano, C. 1
  2. Aspiroz, C. 2
  3. Ara, M. 3
  4. Gómez-Sanz, E. 1
  5. Zarazaga, M. 1
  6. Torres, C. 1
  1. 1 Universidad de La Rioja
    info

    Universidad de La Rioja

    Logroño, España

    ROR https://ror.org/0553yr311

  2. 2 Unidad de Microbiología, Hospital Royo Villanova, Spain
  3. 3 Hospital Clínico Universitario Lozano Blesa
    info

    Hospital Clínico Universitario Lozano Blesa

    Zaragoza, España

    ROR https://ror.org/03fyv3102

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Revista:
Clinical Microbiology and Infection

ISSN: 1198-743X

Año de publicación: 2011

Volumen: 17

Número: 6

Páginas: 923-927

Tipo: Artículo

DOI: 10.1111/J.1469-0691.2010.03437.X PMID: 21682806 SCOPUS: 2-s2.0-79959291024 WoS: WOS:000292385300026 GOOGLE SCHOLAR

Otras publicaciones en: Clinical Microbiology and Infection

Proyectos relacionados

Detección y caracterización genética de Staphylococcus aureus resistente a meticilina en distintos ecosistemas: humanos, animales, alimentos y medioambiente. Impicaciones en salud humana.

2009/00204/001

Resumen

Skin infection associated with methicillin-resistant Staphylococcus aureus (MRSA)-ST398 was detected in a pig-farmer, and MRSA-ST398 isolates were also detected in nasal samples of the patient and of 11/12 pigs on his farm. Twelve MRSA isolates were obtained from skin lesions (n=6) and nasal samples (n=6) of the patient in two sampling moments and 11 MRSA isolates from nasal samples of pigs. They were typed as t011-SCCmecIVa-agrI and t108-SCCmecV-agrI (patient and pigs) and t588-SCCmecV-agrI (patient). The following resistance genes were detected (number isolates): tet(K) (1), tet(L) (23), tet(M) (13), erm(A) (13), erm(C) (13), msr(A) (11), lnu(A) (21), aph(2'')-acc(6') (3), ant(4') (13), aph(3') (12), dfrS1 (15) and dfrK (22). Seventeen human and animal MRSA-ST398 isolates showed indistinguishable PFGE patterns (A1-spa-t011 or B2-spa-t108) and similar phenotypic-genotypic characteristics, including the presence of the lnu(A) gene, associated with lincomycin resistance. Potential pig-to-human transference of ST398 is suggested in this study. The first detection of the lnu(A) gene in MRSA-ST398 is reported. © 2010 The Authors. Clinical Microbiology and Infection © 2010 European Society of Clinical Microbiology and Infectious Diseases.