Expression of the aac(6′)-Ib-cr gene in class 1 integrons

  1. Raherison, S. 234
  2. Jove, T. 234
  3. Gaschet, M. 234
  4. Pinault, E. 4
  5. Tabesse, A. 234
  6. Torres, C. 1
  7. Ploy, M.-C. 234
  1. 1 Universidad de La Rioja
    info

    Universidad de La Rioja

    Logroño, España

    ROR https://ror.org/0553yr311

  2. 2 Centre Hospitalier Universitaire de Limoges
    info

    Centre Hospitalier Universitaire de Limoges

    Limoges, Francia

    ROR https://ror.org/01tc2d264

  3. 3 French Institute of Health and Medical Research
    info

    French Institute of Health and Medical Research

    París, Francia

    ROR https://ror.org/02vjkv261

  4. 4 University of Limoges
    info

    University of Limoges

    Limoges, Francia

    ROR https://ror.org/02cp04407

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Journal:
Antimicrobial Agents and Chemotherapy

ISSN: 0066-4804

Year of publication: 2017

Volume: 61

Issue: 5

Type: Article

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DOI: 10.1128/AAC.02704-16 SCOPUS: 2-s2.0-85018173646 WoS: WOS:000403532100087 GOOGLE SCHOLAR

More publications in: Antimicrobial Agents and Chemotherapy

Abstract

aac(6′)-Ib-cr is a plasmid-mediated quinolone resistance gene embedded within a gene cassette, most often within an integron. It confers resistance to quinolones and aminoglycosides. We investigated the role of a 101-bp fragment frequently present upstream of the aac(6′)-Ib-cr gene cassette and found that it contributes to the expression of aac(6′)-Ib-cr and provides an alternative start codon, confirming the length of the AAC(6′)-Ib-cr protein to 199 amino acids. Copyright © 2017 American Society for Microbiology. All Rights Reserved.