Chemical interrogation of drug/RNA complexes: From chemical reactivity to drug design

  1. Jiménez-Moreno, E. 1
  2. Gómez-Pinto, I. 2
  3. Corzana, F. 3
  4. Santana, A.G. 1
  5. Revuelta, J. 1
  6. Bastida, A. 1
  7. Jiménez-Barbero, J. 4
  8. González, C. 2
  9. Asensio, J.L. 1
  1. 1 Instituto de Química Orgánica General
    info

    Instituto de Química Orgánica General

    Madrid, España

    ROR https://ror.org/05e0q7s59

  2. 2 Instituto de Química Física Rocasolano
    info

    Instituto de Química Física Rocasolano

    Madrid, España

    ROR https://ror.org/03xk60j79

  3. 3 Universidad de La Rioja
    info

    Universidad de La Rioja

    Logroño, España

    ROR https://ror.org/0553yr311

  4. 4 Centro de Investigaciones Biológicas
    info

    Centro de Investigaciones Biológicas

    Madrid, España

    ROR https://ror.org/04advdf21

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Journal:
Angewandte Chemie International

ISSN: 1433-7851

Year of publication: 2013

Volume: 52

Issue: 11

Pages: 3148-3151

Type: Article

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DOI: 10.1002/ANIE.201209434 SCOPUS: 2-s2.0-84874863550 WoS: WOS:000316340700013 GOOGLE SCHOLAR lock_openOpen access editor

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Abstract

When you're in a (RNA) bind: An NMR-based method to explore the reactivity of ligand/RNA complexes can be used as source of valuable information for drug design. By combining NMR spectroscopy and a simple isotopic labeling strategy (see picture), positional chemical reactivity information can be readily extracted from complex aminoglycoside mixtures. C green, N blue, O red, Me purple. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.