A link between host plant adaptation and pesticide resistance in the polyphagous spider mite Tetranychus urticae

  1. Dermauw, W. 2
  2. Wybouw, N. 2
  3. Rombauts, S. 24
  4. Menten, B. 2
  5. Vontas, J. 5
  6. Grbić, M. 37
  7. Clark, R.M. 1
  8. Feyereisen, R. 6
  9. Van Leeuwen, T. 2
  1. 1 University of Utah
    info

    University of Utah

    Salt Lake City, Estados Unidos

    ROR https://ror.org/03r0ha626

  2. 2 Ghent University
    info

    Ghent University

    Gante, Bélgica

    ROR https://ror.org/00cv9y106

  3. 3 University of Western Ontario
    info

    University of Western Ontario

    London, Canadá

    ROR https://ror.org/02grkyz14

  4. 4 Flanders Institute for Biotechnology
    info

    Flanders Institute for Biotechnology

    Gante, Bélgica

    ROR https://ror.org/03xrhmk39

  5. 5 University of Crete
    info

    University of Crete

    Heraklion, Grecia

    ROR https://ror.org/00dr28g20

  6. 6 Institut National de la Recherche Agronomique
    info

    Institut National de la Recherche Agronomique

    París, Francia

  7. 7 Instituto de Ciencias de la Vid y del Vino
    info

    Instituto de Ciencias de la Vid y del Vino

    Logroño, España

    ROR https://ror.org/01rm2sw78

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Revista:
Proceedings of the National Academy of Sciences of the United States of America

ISSN: 0027-8424

Año de publicación: 2013

Volumen: 110

Número: 2

Páginas: E113-E122

Tipo: Artículo

DOI: 10.1073/PNAS.1213214110 SCOPUS: 2-s2.0-84872171542 WoS: WOS:000313906600005 GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Proceedings of the National Academy of Sciences of the United States of America

Repositorio institucional: lock_openAcceso abierto Editor

Resumen

Plants produce a wide range of allelochemicals to defend against herbivore attack, and generalist herbivores have evolved mechanisms to avoid, sequester, or detoxify a broad spectrum of natural defense compounds. Successful arthropod pests have also developed resistance to diverse classes of pesticides and this adaptation is of critical importance to agriculture. To test whether mechanisms to overcome plant defenses predispose the development of pesticide resistance, we examined adaptation of the generalist two-spotted spider mite, Tetranychus urticae, to host plant transfer and pesticides. T. urticae is an extreme polyphagous pest with more than 1,100 documented hosts and has an extraordinary ability to develop pesticide resistance. When mites from a pesticidesusceptible strain propagated on bean were adapted to a challenging host (tomato), transcriptional responses increased over time with ∼7.5% of genes differentially expressed after five generations. Whereas many genes with altered expression belonged to known detoxification families (like P450 monooxygenases), new gene families not previously associated with detoxification in other herbivores showed a striking response, including ring-splitting dioxygenase genes acquired by horizontal gene transfer. Strikingly, transcriptional profiles of tomato-adapted mites resembled those of multipesticide-resistant strains, and adaptation to tomato decreased the susceptibility to unrelated pesticide classes. Our findings suggest key roles for both an expanded environmental response gene repertoire and transcriptional regulation in the life history of generalist herbivores. They also support a model whereby selection for the ability to mount a broad response to the diverse defense chemistry of plants predisposes the evolution of pesticide resistance in generalists.