Asymmetric Synthesis of Exo-Norbornane-2-Carboxylic Acid
- Avenoza, A. 1
- Bueno, M.P. 2
- Cativiela, C. 2
- Mayoral, José A. . 2
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1
Universidad de La Rioja
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2
Instituto de Nanociencia y Materiales de Aragón
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ISSN: 0957-4166
Any de publicació: 1992
Volum: 3
Número: 3
Pàgines: 343-346
Tipus: Article
Altres publicacions en: Tetrahedron: Asymmetry
Resum
The reaction between N-acryloyl-N-methyl-L-alanine methyl ester and cyclopentadiene is studied. The configuration of the cycloadducts preferably obtained depends on the reaction conditions and the Lewis acid used as a catalyst. In TiCl4-catalyzed reactions, high exo:endo ratios and good diastereomeric excesses in exo cycloadducts are obtained under several conditions. So an interesting method for the asymmetric synthesis of derivatives of exo- norbornane-2-carboxylic acid is described.