Unusual presence of the immune evasion gene cluster in livestock-associated MRSA of lineage CC398 causing peridural and psoas abscesses in a poultry farmer

  1. Pérez-Moreno, M.O. 4
  2. Centelles-Serrano, M.J. 4
  3. Nogales-López, J. 5
  4. Domenech-Spanedda, M.F. 6
  5. Lozano, C. 1
  6. Torres, C. 2
  1. 1 Centro de Investigación Biomédica de La Rioja
    info

    Centro de Investigación Biomédica de La Rioja

    Logroño, España

    ROR https://ror.org/03vfjzd38

  2. 2 Universidad de La Rioja
    info

    Universidad de La Rioja

    Logroño, España

    ROR https://ror.org/0553yr311

  3. 3 Institut d'Investigació Sanitària Pere Virgili
    info

    Institut d'Investigació Sanitària Pere Virgili

    Reus, España

  4. 4 Laboratori Clínic ICS-Terres de l'Ebre (Área de microbiología), Hospital de Tortosa Verge de la Cinta, Tortosa (Tarragona), Spain
  5. 5 Servicio de Cirugía Ortopédica y Traumatología, Hospital de Tortosa Verge de la Cinta, Tortosa (Tarragona), Spain
  6. 6 Servicio de Medicina Preventiva, Hospital de Tortosa Verge de la Cinta, Tortosa (Tarragona), Spain
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Revista:
Enfermedades Infecciosas y Microbiologia Clinica

ISSN: 0213-005X

Año de publicación: 2017

Volumen: 35

Número: 10

Páginas: 651-654

Tipo: Artículo

DOI: 10.1016/J.EIMC.2016.07.008 SCOPUS: 2-s2.0-84994126381 WoS: WOS:000418728800007 GOOGLE SCHOLAR

Otras publicaciones en: Enfermedades Infecciosas y Microbiologia Clinica

Resumen

Objective: To characterize a methicillin-resistant . Staphylococcus aureus (MRSA) isolate responsible for an aggressive infection (peridural and psoas abscess secondary to haematogenous septic arthritis) in a poultry farmer. Methods: Molecular characterization was performed, including . spa- and multilocus sequence typing of the isolate, assessment of its resistance phenotype and detection of tetracycline resistance and of virulence and immune evasion cluster (IEC) genes were performed. Results: The MRSA isolate was tetracycline- and fluorquinolone-resistant, and was ascribed to CC398, . spa-t1451. The isolate harboured . tet(M) (distinctive of livestock-associated (LA) MRSA-CC398 clade) and IEC-type B system (characteristic of the methicillin-susceptible human lineage, but typically absent in LA-MRSA-CC398 strains), and lacked toxin-coding genes . lukF/lukS-PV, . tsst-1, . eta and . etb. Conclusion: IEC re-acquisition by LA-MRSA-CC398-LA strains is an unusual finding, but could constitute an emerging public health problem. It would represent an evolutionary step towards LA-MRSA-CC398's adaptation to human hosts, and might enhance its invasiveness and ability to be transmitted to humans. © 2016 Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica.