A Versatile Synthesis of Pyrrolo-, Furo- and Thienopyridines via Photocyclization Induced of 3-Amino-2-alkene Imines in an Acid Medium
- Campos, P.J. 1
- Añón, E. 1
- Carmen Malo, M. 1
- Rodríguez, M.A. 1
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1
Universidad de La Rioja
info
ISSN: 0040-4020
Datum der Publikation: 1999
Ausgabe: 55
Nummer: 49
Seiten: 14079-14088
Art: Artikel
Andere Publikationen in: Tetrahedron
Zusammenfassung
We describe the synthesis of pyrrolo-, furo- and thieno[3,2-b]pyridines substituted by alkyl-, arylamino or NH 2 groups from irradiation of 2- pyrrolyl-, 2-furyl-, and 2-thienylalkene imines under mild reaction conditions. We also describe the irradiation of 3-pyrrolyl-, 3-furyl-, and 3- thienylalkene imines, which yields pyrrolo[3,2-c]pyridines in all cases. The mechanism for this procedure is proposed. The compounds obtained can potentially be used in medicinal chemistry.