Development and Validation of Chromatographic Methods (L.C. and G.C.) for the Determination of the Active Components (Benzocaine, Tyrothricin and Menthol) of a Pharmaceutical Preparation

  1. Ortiz-Boyer, F. 1
  2. Tena, M.T. 1
  3. Luque de Castro, M.D. 1
  4. Valcárcel, M. 1
  1. 1 Universidad de Córdoba (Colombia)
    info

    Universidad de Córdoba (Colombia)

    Montería, Colombia

    ROR https://ror.org/04nmbd607

Revue:
Journal of Pharmaceutical and Biomedical Analysis

ISSN: 0731-7085

Année de publication: 1995

Volumen: 13

Número: 11

Pages: 1297-1303

Type: Article

DOI: 10.1016/0731-7085(95)01557-2 PMID: 8634346 SCOPUS: 2-s2.0-0028789957 GOOGLE SCHOLAR

D'autres publications dans: Journal of Pharmaceutical and Biomedical Analysis

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Résumé

Methods are reported for the determination of tyrothricin and benzocaine by in the analysis of throat lozenges (tablets) containing all three compounds. After optimization of the variables involved in both HPLC and GC the methods hate been characterized and validated according to the guidelines of the Spanish Pharmacopoeia, and applied to both the monitoring of the manufacturing. process and the quality control of the final product.