Organometallic approach to polymer-protected antibacterial silver nanoparticles: optimal nanoparticle size-selection for bacteria interaction

  1. Crespo, J. 2
  2. García-Barrasa, J. 2
  3. López-de-Luzuriaga, J.M. 2
  4. Monge, M. 2
  5. Olmos, M.E. 2
  6. Sáenz, Y. 1
  7. Torres, C. 12
  1. 1 Centro de Investigación Biomédica de La Rioja
    info

    Centro de Investigación Biomédica de La Rioja

    Logroño, España

    ROR https://ror.org/03vfjzd38

  2. 2 Universidad de La Rioja
    info

    Universidad de La Rioja

    Logroño, España

    ROR https://ror.org/0553yr311

Revista:
Journal of Nanoparticle Research

ISSN: 1388-0764

Año de publicación: 2012

Volumen: 14

Número: 12

Páginas: 1-13

Tipo: Artículo

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DOI: 10.1007/S11051-012-1281-Y SCOPUS: 2-s2.0-84868336482 WoS: WOS:000312894200026 GOOGLE SCHOLAR

Otras publicaciones en: Journal of Nanoparticle Research

Resumen

The optimal size-specific affinity of silver nanoparticles (Ag NPs) towards E. coli bacteria has been studied. For this purpose, Ag NPs coated with polyvinylpyrrolidone (PVP) and cellulose acetate (CA) have been prepared using an organometallic approach. The complex NBu4[Ag(C6F 5)2] has been treated with AgClO4 in a 1:1 molar ratio giving rise to the nanoparticle precursor [Ag(C6F 5)] in solution. Addition of an excess of PVP (1) or CA (2) and 5 h of reflux in tetrahydrofuran (THF) at 66 °C leads to Ag NPs of small size (4.8 ± 3.0 nm for PVP-Ag NPs and 3.0 ± 1.2 nm for CA-Ag NPs) that coexist in both cases with larger nanoparticles between 7 and 25 nm. Both nanomaterials display a high antibacterial effectiveness against E. coli. The TEM analysis of the nanoparticle-bacterial cell membrane interaction shows an optimal size-specific affinity for PVP-Ag NPs of 5.4 ± 0.7 nm in the presence of larger size silver nanoparticles. © Springer Science+Business Media Dordrecht 2012.