Changes in ciprofloxacin resistance levels in Enterobacter aerogenes isolates associated with variable expression of the aac(6′)-Ib-cr gene
- Ruiz, E. 5
- Ocampo-Sosa, A.A. 3
- Alcoba-Flórez, J. 4
- Román, E. 3
- Arlet, G. 1
- Torres, C. 5
- Martínez-Martínez, L. 23
-
1
Pierre and Marie Curie University
info
Pierre and Marie Curie University
París, Francia
-
2
Universidad de Cantabria
info
-
3
Hospital Universitario Marqués de Valdecilla
info
-
4
Hospital Universitario Nuestra Señora de Candelaria
info
Hospital Universitario Nuestra Señora de Candelaria
Santa Cruz de Tenerife, España
-
5
Universidad de La Rioja
info
ISSN: 0066-4804
Any de publicació: 2012
Volum: 56
Número: 2
Pàgines: 1097-1100
Tipus: Article
Altres publicacions en: Antimicrobial Agents and Chemotherapy
Resum
Two closely related Enterobacter aerogenes isolates presented a new identical aac(6′)-Ib-cr genetic environment, including IS26. One isolate showed lower MICs of ciprofloxacin, norfloxacin, tobramycin, and amikacin and decreased expression of aac(6′)-Ibcr, which might be related to a 12-bp deletion causing a displacement of the -10 box upstream of the aac(6′)-Ib-cr gene. Copyright © 2012, American Society for Microbiology. All Rights Reserved.