Pressurized liquid extraction with in-cell clean-up followed by gas chromatography-tandem mass spectrometry for the selective determination of parabens and triclosan in indoor dust

  1. Canosa, P. 1
  2. Pérez-Palacios, D. 2
  3. Garrido-López, A. 2
  4. Tena, M.T. 2
  5. Rodríguez, I. 1
  6. Rubí, E. 1
  7. Cela, R. 1
  1. 1 Universidade de Santiago de Compostela
    info

    Universidade de Santiago de Compostela

    Santiago de Compostela, España

    ROR https://ror.org/030eybx10

  2. 2 Universidad de La Rioja
    info

    Universidad de La Rioja

    Logroño, España

    ROR https://ror.org/0553yr311

Revista:
Journal of Chromatography A

ISSN: 0021-9673

Año de publicación: 2007

Volumen: 1161

Número: 1-2

Páginas: 105-112

Tipo: Artículo

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DOI: 10.1016/J.CHROMA.2007.05.089 PMID: 17585923 SCOPUS: 2-s2.0-34447623178 WoS: WOS:000248891500016 GOOGLE SCHOLAR

Otras publicaciones en: Journal of Chromatography A

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INOVACIONES ANALITICAS EN LA DETERMINACION DIRECTA DE VOLATILES Y EN LA MIGRACION DE COMPUESTOS ORGANICOS EN SOLIDOS

2004/00090/001

Resumen

A sample preparation method based on the use of pressurized liquid extraction is proposed for the determination of four alkyl parabens and triclosan in indoor dust. Extraction of analytes and removal of interfering species were achieved in the same step, by placing an appropriate sorbent in the extraction cell and by choosing a right combination of washing and elution solvents. Compounds, as silylated derivatives, were determined by gas chromatography in combination with tandem mass spectrometry (GC-MS/MS). Factors affecting the yield and selectivity of the sample preparation procedure were carefully evaluated. Under final conditions, dried samples (0.5 g of dust and 1 g of sodium sulphate) were dispersed with 3 g of Florisil and loaded into an 11 mL stainless-steel extraction cell containing 1 g of the same material as clean-up sorbent. Non-polar species were removed with n-hexane under mild conditions (40 °C, 3.4 MPa) and then analytes were extracted with ethyl acetate. The best compromise extraction conditions were 103 °C, 13.8 MPa and 3 static extraction cycles of 1 min. The proposed method provided recoveries from 76 to 98%, relative standard deviations under 11% (operating under reproducibility conditions) and quantification limits from 1 to 4 ng/g. The analysis of dust samples from private houses and office buildings confirmed the ubiquitous presence of target bactericides in these environments. © 2007 Elsevier B.V. All rights reserved.