Vaccination against hepatitis B virus in Spain: a cost-effectiveness analysis

  1. Garuz, R. 27
  2. Torrea, J.L. 5
  3. Arnal, J.M. 1
  4. Forcen, T. 8
  5. Trinxet, C. 3
  6. Anton, F. 6
  7. Antoñanzas, F. 4
  1. 1 Actur Health Center, Zaragoza, Spain
  2. 2 C/Julio Garcia Condoy, 17. 4o B., 50015 Zaragoza, Spain
  3. 3 Catalonian Health Service, Barcelona, Spain
  4. 4 Universidad de La Rioja
    info

    Universidad de La Rioja

    Logroño, España

    ROR https://ror.org/0553yr311

  5. 5 Universidad Autónoma de Madrid
    info

    Universidad Autónoma de Madrid

    Madrid, España

    ROR https://ror.org/01cby8j38

  6. 6 Hospital San Pedro
    info

    Hospital San Pedro

    Logroño, España

    ROR https://ror.org/031va0421

  7. 7 Primary Care Direction, Area 3, Zaragoza, Spain
  8. 8 Tafalla Health Center, Navarra, Spain
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Journal:
Vaccine

ISSN: 0264-410X

Year of publication: 1997

Volume: 15

Issue: 15

Pages: 1652-1660

Type: Article

DOI: 10.1016/S0264-410X(97)00083-2 PMID: 9364696 SCOPUS: 2-s2.0-0030863064 WoS: WOS:A1997YB29800009 GOOGLE SCHOLAR

More publications in: Vaccine

Institutional repository: lock_openOpen access Editor

Abstract

A cost-effectiveness analysis was made to determine the effectiveness of the following strategies of mass immunization with the new recombinant vaccine against the hepatitis B virus in Spain: vaccination of-adolescents, newborns, both populations, and vaccination plus passive immunization of newborns of HBsAg positive mothers. Decision trees supported on Markov models with Monte Carlo simulation have been used for the calculation of costs of the disease, and a mathematical model of differential equations was used for the simulation of the potential effectiveness of vaccination. The costs considered were those associated with the vaccination and travel of subjects, diagnosis, and treatment of the disease. The results are presented as additional cost or saving per case of infection prevented In all assumptions, results showed that the most effective strategy for mass vaccination was the combination of vaccinating all adolescents together with active and passive immunization of children born to HBsAg positive mothers.