A survey of tools for analysing DNA fingerprints

  1. Heras, J. 1
  2. Domínguez, C. 1
  3. Mata, E. 1
  4. Pascual, V. 1
  5. Lozano, C. 1
  6. Torres, C. 1
  7. Zarazaga, M. 1
  1. 1 Universidad de La Rioja
    info

    Universidad de La Rioja

    Logroño, España

    ROR https://ror.org/0553yr311

Revista:
Briefings in Bioinformatics

ISSN: 1467-5463

Año de publicación: 2016

Volumen: 17

Número: 6

Páginas: 903-911

Tipo: Artículo

DOI: 10.1093/BIB/BBV016 PMID: 25825453 SCOPUS: 2-s2.0-85038129383 WoS: WOS:000392716500001 GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Briefings in Bioinformatics

Repositorio institucional: lock_openAcceso abierto Postprint lock_openAcceso abierto Editor

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Resumen

DNA fingerprinting is a genetic typing technique that allows the analysis of the genomic relatedness between samples, and the comparison of DNA patterns. This technique has multiple applications in different fields (medical diagnosis, forensic science, parentage testing, food industry, agriculture and many others). An important task in molecular epidemiology of infectious diseases is the analysis and comparison of pulsed-field gel electrophoresis (PFGE) patterns. This is applied to determine the clonal diversity of bacteria in the follow-up of outbreaks or for tracking specific clones of special relevance. The resulting images produced by DNA fingerprinting are sometimes difficult to interpret, and multiple tools have been developed to simplify this task. In this article, we present a survey of tools for analysing DNA fingerprints. In particular, we compare 33 tools using a set of predefined criteria. The comparison was carried out by hands-on experiences-whenever possible-and inspecting the documentation of the tools. As no system is preferred in all the possible scenarios, we have created a spreadsheet that can be customized by researchers to determine the best system for their needs.