PROYECTOS I+D
Proxecto CTQ2015-67727-R GLYCOMUC
Diseño estructural de glicopeptidos de tipo mucina que incorporan miméticos del antigeno TN para desarrollar biomarcadores y vacunas contra el cáncer.
De ámbito Nacional.
Investigadores/as
Publicacións relacionadas co proxecto (32)
Mostrar por tipoloxía2019
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Structure-Based Design of Potent Tumor-Associated Antigens: Modulation of Peptide Presentation by Single-Atom O/S or O/Se Substitutions at the Glycosidic Linkage
Journal of the American Chemical Society
2018
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Nuevos deshidroaminoácidos quirales
GUTIÉRREZ JIMÉNEZ, MARTA ISABEL
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Structure-based design of glycopeptides featuring unnatural tn antigens and their applications to cancer vaccination and diagnosis
Bermejo Ruiz, Iris Alicia
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Tn Antigen Mimics by Ring-Opening of Chiral Cyclic Sulfamidates with Carbohydrate C1- S- and C1- O-Nucleophiles
Journal of Organic Chemistry
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Cell-Penetrating Peptides Containing Fluorescent d-Cysteines
Chemistry - A European Journal
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Structural Analysis of a GalNAc-T2 Mutant Reveals an Induced-Fit Catalytic Mechanism for GalNAc-Ts
Chemistry - A European Journal
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Enhanced Permeability and Binding Activity of Isobutylene-Grafted Peptides
Chembiochem : a European journal of chemical biology
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A Late-Stage Synthetic Approach to Lanthionine-Containing Peptides via S-Alkylation on Cyclic Sulfamidates Promoted by Molecular Sieves
Organic Letters
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Water Sculpts the Distinctive Shapes and Dynamics of the Tumor-Associated Carbohydrate Tn Antigens: Implications for Their Molecular Recognition
Journal of the American Chemical Society
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Oxygen by Carbon Replacement at the Glycosidic Linkage Modulates the Sugar Conformation in Tn Antigen Mimics
ACS Omega
2017
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The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences
Nature Communications
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Principles of mucin structure: Implications for the rational design of cancer vaccines derived from MUC1-glycopeptides
Chemical Society Reviews
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Substituent Effects on the Reactivity of Cyclic Tertiary Sulfamidates
Journal of Organic Chemistry
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The Use of Fluoroproline in MUC1 Antigen Enables Efficient Detection of Antibodies in Patients with Prostate Cancer
Journal of the American Chemical Society
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Oxetane Grafts Installed Site-Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo
Angewandte Chemie International
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Site-Selective Modification of Proteins with Oxetanes
Chemistry - A European Journal
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A Water-Bridged Cysteine-Cysteine Redox Regulation Mechanism in Bacterial Protein Tyrosine Phosphatases
Chem
2016
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Síntesis de a/ß-péptidos híbridos tioglicosilados mediante apertura de sulfamidatos cíclicos
García Gonzalez, Iván
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Reacciones de metátesis e hidrotiolación como herramientas sintéticas para la obtención de compuestos con interés biológico
Rojas Ocáriz, Víctor
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Mucin Architecture behind the Immune Response: Design and Evaluation of an Antitumor Vaccine Derived from an Unnatural MUC1 Fragment
Chemical Science
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Design of α-S-Neoglycopeptides Derived from MUC1 with a Flexible and Solvent-Exposed Sugar Moiety
Journal of Organic Chemistry
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Tn Antigen Mimics Based on sp2-Iminosugars with Affinity for an anti-MUC1 Antibody
Organic Letters
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Bifunctional Chiral Dehydroalanines for Peptide Coupling and Stereoselective S-Michael Addition
Organic Letters
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Conformationally-locked C-glycosides: tuning aglycone interactions for optimal chaperone behaviour in Gaucher fibroblasts
Organic and Biomolecular Chemistry
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A proactive role of water molecules in acceptor recognition by protein O-fucosyltransferase 2
Nature Chemical Biology
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Chondroitin Sulfate Tetrasaccharides: Synthesis, Three-Dimensional Structure and Interaction with Midkine
Chemistry - A European Journal
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Quillaja saponin variants with central glycosidic linkage modifications exhibit distinct conformations and adjuvant activities
Chemical Science
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Finding the Right Candidate for the Right Position: A Fast NMR-Assisted Combinatorial Method for Optimizing Nucleic Acids Binders
Journal of the American Chemical Society
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Unraveling the Conformational Landscape of Ligand Binding to Glucose/Galactose-Binding Protein by Paramagnetic NMR and MD Simulations
ACS chemical biology
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Diastereomeric Glycosyl Sulfoxides Display Different Recognition Features versus E. coli β-Galactosidase
European Journal of Organic Chemistry
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Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents
Nature Communications
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Unveiling (−)-Englerin A as a Modulator of L-Type Calcium Channels
Angewandte Chemie International