Budget impact analysis of a pneumococcal vaccination programme in the 65-year-old Spanish cohort using a dynamic model

  1. Pradas, R. 1
  2. Gil de Miguel, Angel. 2
  3. Álvaro, A. 2
  4. Gil-Prieto, R. 2
  5. Lorente, R. 1
  6. Méndez, C. 3
  7. Guijarro, P. 3
  8. Antoñanzas, F. 1
  1. 1 Universidad de La Rioja
    info

    Universidad de La Rioja

    Logroño, España

    ROR https://ror.org/0553yr311

  2. 2 Universidad Rey Juan Carlos
    info

    Universidad Rey Juan Carlos

    Madrid, España

    ROR https://ror.org/01v5cv687

  3. 3 Pfizer Spain, Alcobendas, Madrid, Spain
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Revista:
BMC Infectious Diseases

ISSN: 1471-2334

Año de publicación: 2013

Volumen: 13

Número: 1

Páginas: 1-8

Tipo: Artículo

DOI: 10.1186/1471-2334-13-175 SCOPUS: 2-s2.0-84875931551 WoS: WOS:000318559900004 GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: BMC Infectious Diseases

Repositorio institucional: lock_openAcceso abierto Editor

Resumen

Background: This study aimed to assess the costs and clinical benefits of the 13-valent pneumococcal conjugate vaccine (PCV13) administered annually to the 65-year-old cohort in Spain versus the alternative of not vaccinating patients and treating them only when infected.Methods: Cases of pneumococcal disease avoided were calculated through a dynamic model based on the work of Anderson and May (1999). Sixty-six percent of the 65-year-old cohort was assumed to have been vaccinated with one PCV13 dose (304,492 subjects). Base-case estimated vaccine effectiveness and serotype coverage were 58% and 60%, respectively. Disease-related costs were calculated based on published data.Results: Over the 5-year period, a total of 125,906 cases of pneumococcal disease would be avoided. Net savings of €102 million would be obtained. The cost-saving distribution was not homogeneous, starting in the 2nd year and increasing through the 5th. To demonstrate model robustness, an additional scenario analysis was performed using extreme values of model parameters (vaccination programme coverage, vaccine effectiveness, discount rate and disease costs). Under those scenarios, net savings were always achieved.Conclusions: Based on the assumptions of the model, the 65-year-cohort pneumococcal vaccination campaign appears to be a cost-saving intervention in the Spanish population under different scenarios. © 2013 Pradas et al.; licensee BioMed Central Ltd.