Synthesis and conformational analysis of neoglycoconjugates derived from O- and S-glucose
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Universidad de La Rioja
info
ISSN: 0008-6215
Year of publication: 2013
Volume: 373
Pages: 1-8
Type: Article
More publications in: Carbohydrate Research
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Abstract
Using olefin metathesis as a key step, four neoglycoconjugates incorporating α-. O-glucose, α-. S-glucose or β-. S-glucose as a carbohydrate unit and l-serine or l-cysteine as an amino acid moiety have been synthesized. The four-atom carbon spacer allows the carbohydrate to explore a wide-ranging conformational space, which may have important implications for the molecular recognition of these molecules. © 2013 Elsevier Ltd.