Regioselective Ring-Opening Metathesis-Cross Metathesis of Bridgehead-Substituted 7-Azanorbornene
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Universidad de La Rioja
info
ISSN: 1523-7060
Year of publication: 2007
Volume: 9
Issue: 7
Pages: 1235-1238
Type: Article
More publications in: Organic Letters
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Abstract
Figure presented In this paper we describe a highly regioselective ring-opening metathesis-cross metathesis (ROM-CM) process between methyl N-Boc-7-azabicyclo[2.2.1]hept-2-en-1-carboxylate, a bridgehead-substituted 7-azanorbornene system, and electron-poor olefins. The reaction opens the way to the synthesis of interesting α-amino diacids and pyrrolizinone derivatives that incorporate quaternary stereocenters. © 2007 American Chemical Society.